Topics
From Structural Genomics to Drug Discovery: Modeling the Flexibility.
Course 2007
Since the first course “From Structural Biology to Drug Discovery” was held in Parma in 2000, several “-omics” projects - the Genomics, Pharmacogenomics, Proteomics – have opened up great opportunities for the discovery of new targets, the characterization of abnormal protein patterns, the selection of “tailored” drugs and the evaluation of drug efficacy. Furthermore, structure-based drug design, computational methods for in silico screening and nanobiotechnology-based tools are simplifying the time-consuming and money-intensive research of lead compounds and, possibly, drugs.
In order to simulate the actual behaviour of biomolecules, we must take into account that flexibility is a key property linking structure to function.
The Course 2007 (the fifth edition) “From Structural Genomics to Drug Discovery: Modeling the Flexibility” is designed to present:
- an overview on the fundamental concepts about the flexibility in protein function;
- how to manage data coming from x-ray crystallography and nuclear magnetic resonance normally used for virtual screening;
- the state of the art in the development of theoretical approaches to face up protein flexibility;
- computational approaches to include protein flexibility within software for in silico screening;
- experimental applications and case studies where this kind of approach has been applied.
The maximum number of participants is limited to 120 people
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